New Treatments for Traumatic Brain Injury

Grant number: 1061587 | Funding period: 2014 - 2016

Completed

Abstract

Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance similar to another protein called ceruloplasmin (CP). Both, prevalently found in the brain, convert a damaging iron variety into the safer form. Disruption in either protein leads to cell death. We aim to establish how failure in APP and CP response may be detrimental to traumatic brain injury recovery. Understanding the iron role of APP and CP will lead to therapeutics to counter traumatic injury.

Related publications (5)

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Lower levels of soluble β-amyloid precursor protein, but not β-amyloid, in the frontal cortex in schizophrenia

Brian Dean, James Duce, Qiao-Xin Li, Colin L Masters, Elizabeth Scarr

2024-01-01

We identified a sub-group (25%) of people with schizophrenia (muscarinic receptor deficit schizophrenia (MRDS)) that are character..

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The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing

A Tsatsanis, AN McCorkindale, BX Wong, E Patrick, TM Ryan, RW Evans, AI Bush, GT Sutherland, A Sivaprasadarao, B Guennewig, JA Duce

2021-10-01

Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extrac..

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Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention

A Tsatsanis, BX Wong, AP Gunn, S Ayton, AI Bush, D Devos, JA Duce

2020-09-01

The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis..

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Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

A Tsatsanis, S Dickens, JCF Kwok, BX Wong, JA Duce

2019-06-15

Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron..

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Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects

LQ Lam, BX Wong, T Frugier, QX Li, SJ Collins, AI Bush, PJ Crack, JA Duce

2017-04-19

Ferroxidase activity has been reported to be altered in various biological fluids in neurodegenerative disease, but the sources co..

University of Melbourne Researchers